Setting up an HP wireless printer on a Mac involves several steps. Begin by placing the printer within range of your Wi-Fi network. Power on the printer and ensure it's ready for setup. On your Mac, go to "System Preferences" and select "Printers & Scanners." Click the '+' sign to add a printer. The Mac will automatically detect your HP printer. Click on it and then click "Add." Follow any on-screen prompts to complete the setup. Once connected, test a print to ensure successful installation.